Strain Data Sheet

RBRC06397

Strain Information

Image
BRC No.RBRC06397
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Fkbp8<tm1Kei>
Former Common nameFkbp38 KO, B6-Fkbp38 KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 7 times.
Strain descriptionFkbp38 gene knockout mice. Exons 3 to 7 were raplaced with a PGK-neo (loxP-neo) cassette.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.
Shirane M, Ogawa M, Motoyama J, Nakayama K I
Genes to Cells, 13, 635-651 (2008). 18459960

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fkbp8
MGI:1341070		FK506 binding protein 88Fkbp8<tm1Kei> targeted mutation 1, Keiichi I Nakayama
loxP phage P1 loxP8loxP
loxP phage P1 loxP8loxP
neo neomycin resistance gene (E. coli)8 mouse phosphoglycerate kinase promoter (PGK promoter)
SV40 polyA signal8

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal brain morphology(MP:0002152)

  • abnormal cell physiology(MP:0005621)

  • abnormal cerebellum morphology(MP:0000849)

  • abnormal cerebral hemisphere morphology(MP:0008540)

  • abnormal dorsal root ganglion morphology(MP:0000961)
    • more 21 phenotypes
  • abnormal embryonic neuroepithelium morphology(MP:0004261)

  • abnormal embryonic/fetal subventricular zone morphology(MP:0004274)

  • abnormal limb morphology(MP:0002109)

  • abnormal lumbar vertebrae morphology(MP:0003049)

  • abnormal neural tube morphology(MP:0002151)

  • abnormal neuron differentiation(MP:0009937)

  • abnormal rib morphology(MP:0000150)

  • abnormal spinal cord morphology(MP:0000955)

  • abnormal suckling behavior(MP:0001436)

  • abnormal thalamus morphology(MP:0000832)

  • abnormal vertebral arch morphology(MP:0004599)

  • clubfoot(MP:0000576)

  • curly tail(MP:0003051)

  • cyanosis(MP:0001575)

  • decreased body size(MP:0001265)

  • dehydration(MP:0001429)

  • exencephaly(MP:0000914)

  • neonatal lethality, complete penetrance(MP:0011087)

  • respiratory distress(MP:0001954)

  • scoliosis(MP:0000161)

  • spina bifida(MP:0003054)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promoter, E. coli Neomycin resistance gene, SV40 polyA signal, mouse Fkbp8 genomic DNA
    Research applicationCre/loxP system
    Neurobiology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorKeiichi Nakayama (Kyushu University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data