Strain Information | |
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Image | |
BRC No. | RBRC06402 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6;129P2-Cdkn1c<tm2.1Kei> |
Former Common name | p57 cKO, B6-Cdkn1c floxed |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N6 generations). |
Strain description | p57 floxed mice. Exons 2 to 4 were flanked by loxP sites (Flox type). Paternal imprinting gene. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJcl] |
References | p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Matsumoto A, Takeishi S, Kanie T, Susaki E, Onoyama I, Tateishi Y, Nakayama K, Nakayama K I Cell Stem Cell, 9, 262-271 (2011). 21885021 |
Health Report | |
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Examination Date / Room / Rack | 2023/08/28Room:4-CRack:GSentinel mouse program 2023/05/29Room:4-CRack:GSentinel mouse program 2023/02/27Room:4-CRack:GSentinel mouse program |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Cdkn1c MGI:104564 | cyclin dependent kinase inhibitor 1C | 7 | Cdkn1c<tm2.1Kei> MGI:5294426 | targeted mutation 2.1, Keiichi I Nakayama | |||
loxP | phage P1 loxP | 7 | loxP | ||||
loxP | phage P1 loxP | 7 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, mouse Cdkn1c genomic DNA |
Research application | Cancer Research Cell Biology Research Cre/loxP system Metabolism Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. |
Depositor | Keiichi Nakayama (Kyushu University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Lozano-Ureña A, Lázaro-Carot L, Jiménez-Villalba E, Montalbán-Loro R, Mateos-White I, Duart-Abadía P, Martínez-Gurrea I, Nakayama KI, Fariñas I, Kirstein M, Gil-Sanz C, Ferrón SR. IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells. Development 150(1) (2023) 36633189 |