Strain Data Sheet

RBRC06402

Strain Information

Image
BRC No.RBRC06402
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Cdkn1c<tm2.1Kei>
Former Common namep57 cKO, B6-Cdkn1c floxed
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N6 generations).
Strain descriptionp57 floxed mice. Exons 2 to 4 were flanked by loxP sites (Flox type). Paternal imprinting gene.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
References
p57 is required for quiescence and maintenance of adult hematopoietic stem cells.
Matsumoto A, Takeishi S, Kanie T, Susaki E, Onoyama I, Tateishi Y, Nakayama K, Nakayama K I
Cell Stem Cell, 9, 262-271 (2011). 21885021

Health Report

Examination Date / Room / Rack2023/08/28Room:4-CRack:GSentinel mouse program
2023/05/29Room:4-CRack:GSentinel mouse program
2023/02/27Room:4-CRack:GSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cdkn1c
MGI:104564
cyclin dependent kinase inhibitor 1C7Cdkn1c<tm2.1Kei>
MGI:5294426
targeted mutation 2.1, Keiichi I Nakayama
  • Beckwith-Wiedemann syndrome(DisGeNET, MedGEN)

  • IMAGe syndrome(DisGeNET, MedGEN)
  • loxP phage P1 loxP7loxP
    loxP phage P1 loxP7loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
  • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse Cdkn1c genomic DNA
    Research applicationCancer Research
    Cell Biology Research
    Cre/loxP system
    Metabolism Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorKeiichi Nakayama (Kyushu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Lozano-Ureña A, Lázaro-Carot L, Jiménez-Villalba E, Montalbán-Loro R, Mateos-White I, Duart-Abadía P, Martínez-Gurrea I, Nakayama KI, Fariñas I, Kirstein M, Gil-Sanz C, Ferrón SR.
    IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
    Development 150(1) (2023) 36633189