Strain Information | |
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Image | |
BRC No. | RBRC06410 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.Cg-Nfkbiz<tm1.1Muta> |
Former Common name | IκB-ζ flox/flox, B6-Nfkbiz floxed |
H-2 Haplotype | |
ES Cell line | Bruce 4 [B6.Cg-Thy1<a>] |
Background strain | |
Appearance | |
Strain development | Developed by Tatsushi Muta, Graduate School of Life Sciences, Tohoku University. Bruce 4 ES cells were used to generate the mutant mice. A frt-neo cassette was removed by crossing with CAG-FLPe (B6) mice. |
Strain description | Nfkbiz gene floxed mice. Exons 5 to 7 were flanked by loxP sites. |
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJmsSlc] |
References | Enhanced apoptosis by disruption of the STAT3-IkappaB-zeta signaling pathway in epithelial cells induces Sjogren's syndrome-like autoimmune disease. Okuma A, Hoshino K, Ohba T, Fukushi S, Aiba S, Akira S, Ono M, Kaisho T, Muta T Immunity, 38, 450-460 (2013). 23453632 |
Health Report | |
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Examination Date / Room / Rack | 2025/01/07Room:3-BRack:LSentinel mouse program 2024/10/07Room:3-BRack:LSentinel mouse program 2024/07/08Room:3-BRack:LAdditional tests 2024/04/08Room:3-BRack:LSentinel mouse program 2024/01/09Room:3-BRack:LSentinel mouse program 2023/10/10Room:3-BRack:LSentinel mouse program 2023/07/10Room:3-BRack:LSentinel mouse program 2023/04/10Room:3-BRack:LSentinel mouse program 2023/03/24Room:3-BRack:LAdditional tests |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Frt | yeast FRT (flippase recombination target) site | 16 | Frt | ||||
Nfkbiz MGI:1931595 | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta | 16 | Nfkbiz<tm1.1Muta> MGI:5501251 | targeted mutation 1.1, Tatsushi Muta | |||
loxP | phage P1 loxP | 16 | loxP | ||||
loxP | phage P1 loxP | 16 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | P1 phage loxP sites, yeast FRT (flippase recombination target) site, mouse Nfkbiz genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 38, 450-460 (2013). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Takashi Maruyama (Gifu University) |
Strain Status | ![]() ![]() ![]() |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Apr 2017 |
BRC mice in Publications |
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Taylor TC, Coleman BM, Arunkumar SP, Dey I, Dillon JT, Ponde NO, Poholek AC, Schwartz DM, McGeachy MJ, Conti HR, Gaffen SL. IκBζ is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe (2023) 37725983 |
Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol 7(76) eabm9811(2022) 36306369 |
Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal 15(758) eabl5304(2022) 36318619 |
Arra M, Swarnkar G, Ke K, Otero JE, Ying J, Duan X, Maruyama T, Rai MF, O'Keefe RJ, Mbalaviele G, Shen J, Abu-Amer Y. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis. Nat Commun 11(1) 3427(2020) 32647171 |
Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature 577(7789) 260-265(2020) 31853061 |