Strain Data Sheet

RBRC09248

Strain Information

Image
BRC No.RBRC09248
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameCHe.129-Trp53<tm1Brd>
Former Common nameBALB/c-Trp53 KO, BALB-p53 KO
H-2 Haplotype
ES Cell lineAB1 [129S7/SvEvBrd-Hprt<+>]
Background strainBALB/cHeA
Appearance
Strain developmentPeter Demant, The Netherlands Cancer Institute to Osaka Prefecture University. The mutant mice were backcrossed to BALB/cHeA over 10 times.
Strain descriptionTrp53 knockout mice, BALB/cHeA background. Homozygous mutant mice can grow after birth, but die within a few months after birth due to the development of tumors.
Colony maintenanceHeterozygote x Wild-type [or Crossing to BALB/cHeAHiOpu (RBRC09247)]
References
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.
Donehower L A, Harvey M, Slagle B L, McArthur M J, Montgomery C A Jr, Butel J S, Bradley A
Nature. 356(6366), 215-221 (1992). 1552940

Modulations of glucocorticoid-induced apoptosis linked to the p53 deletion and to the apoptosis susceptibility gene Rapop1 (Radiation-induced apoptosis 1).
Mori N, Yamate J, Stassen A P, Oka S, Okumoto M, Tsubura A, Akamatsu T, Sakuma S, Demant P
Oncogene, 18, 4282-4285 (1999). 10435642

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley D M, Ishii K J, Kiyono H, Akira S, Uematsu S
Nat. Commun., 3492 (2014). 24637670

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Trp53
MGI:98834		transformation related protein 5311Trp53<tm1Brd>
MGI:1857590		targeted mutation 1, Allan Bradley
  • adrenal cortex carcinoma(DisGeNET)

  • adrenocortical carcinoma, hereditary(MedGEN)

  • B-cell chronic lymphocytic leukemia(DisGeNET)
    • more 14 Diseases
  • basal cell carcinoma, susceptibility to, 7(MedGEN)

  • bone marrow failure syndrome 5(MedGEN)

  • bone osteosarcoma(MedGEN)

  • breast carcinoma(DisGeNET)

  • choroid plexus papilloma(MedGEN)

  • colorectal cancer(MedGEN)

  • exocrine pancreatic carcinoma(MedGEN)

  • glioma susceptibility 1(MedGEN)

  • glioma(DisGeNET)

  • hepatocellular carcinoma(MedGEN)

  • hereditary breast carcinoma(MedGEN)

  • Li-Fraumeni syndrome(DisGeNET)

  • nasopharyngeal carcinoma(MedGEN)

  • obsolete Li-Fraumeni syndrome 1(MedGEN)
    • neo neomycin resistance gene (E. coli)11 mouse polymerase II promoter

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal cell cycle checkpoint function(MP:0004045)

  • abnormal cell cycle(MP:0003077)

  • abnormal cell physiology(MP:0005621)

  • abnormal chromosome number(MP:0004023)

  • abnormal response to cardiac infarction(MP:0000343)
    • more 24 phenotypes
  • abnormal thymus physiology(MP:0003763)

  • decreased apoptosis(MP:0006043)

  • decreased cellular sensitivity to gamma-irradiation(MP:0003207)

  • decreased cellular sensitivity to ionizing radiation(MP:0004228)

  • decreased incidence of tumors by chemical induction(MP:0004502)

  • decreased neuron apoptosis(MP:0003204)

  • decreased sensitivity to induced cell death(MP:0008944)

  • decreased susceptibility to induced morbidity/mortality(MP:0009764)

  • decreased thymocyte apoptosis(MP:0009542)

  • decreased tumor growth/size(MP:0003447)

  • delayed cellular replicative senescence(MP:0008009)

  • increased T cell derived lymphoma incidence(MP:0002024)

  • increased carcinoma incidence(MP:0002038)

  • increased cell proliferation(MP:0000351)

  • increased cellular glucose import(MP:0003927)

  • increased fibroblast proliferation(MP:0011703)

  • increased hemangiosarcoma incidence(MP:0003667)

  • increased lymphoma incidence(MP:0012431)

  • increased osteosarcoma incidence(MP:0003789)

  • increased rhabdomyosarcoma incidence(MP:0002036)

  • increased sarcoma incidence(MP:0002032)

  • increased tumor incidence(MP:0002020)

  • oxidative stress(MP:0003674)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse polymerase II promoter, E. coli Neomycin resistance gene, mouse Trp53 genomic DNA
    Research applicationCancer Research
    Specific Term and ConditionsThe availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorNobuko Mori (Osaka Prefecture University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data