Strain Data Sheet

RBRC09249

Strain Information

Image
BRC No.RBRC09249
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameCHe(Cg)-Ccdc85c<hhy>
Former Common namehhy, BALB-hhy
H-2 Haplotype
ES Cell line
Background strainBALB/cHeA
Appearance
Strain developmentDeveloped by Nobuko Mori, Osaka Prefecture University. BALB/cHeA background.
Strain descriptionHemorrhagic hydrocephalus mutant mice. Spontaneous mutation, recessive. The incidence of hydrocephalus in homozygous mice decreases with progression of backcrossing to BALB/c.
Colony maintenanceHeterozygote x Heterozygote, Wild-type
References
Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice.
Mori N, Kuwamura M, Tanaka N, Hirano R, Nabe M, Ibuki M, Yamate J
Am. J. Physiol., 80(1). 314-327 (2012). 22056358

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ccdc85c
MGI:3644008		coiled-coil domain containing 85C12Ccdc85c<hhy>
MGI:3505575		hemorrhagic hydrocephalus

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cerebellum morphology(MP:0000849)

  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal midbrain morphology(MP:0000897)

  • abnormal nervous system morphology(MP:0003632)

  • abnormal nervous system physiology(MP:0003633)
    • more 7 phenotypes
  • abnormal occipital lobe morphology(MP:0000804)

  • cerebral aqueductal stenosis(MP:0002958)

  • dilated lateral ventricle(MP:0000825)

  • gliosis(MP:0002183)

  • hydrocephaly(MP:0001891)

  • intracranial hemorrhage(MP:0001915)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationMouse Models for Human Disease
    Neurobiology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Am J Pathol. 80(1). 314-327 (2012).The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorNobuko Mori (Osaka Prefecture University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data