Strain Data Sheet

RBRC09260

Strain Information

Image
BRC No.RBRC09260
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Cnga2<tm1Kob>
Former Common nameCNGA2flox
H-2 Haplotype
ES Cell lineEGR-05 [129S2]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice.
Matsuo T, Hattori T, Asaba A, Inoue N, Kanomata N, Kikusui T, Kobayakawa R, Kobayakawa K
Proc. Natl. Acad. Sci. USA, 112(3):E311-20 (2015). 25564662

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cnga2
MGI:108040
cyclic nucleotide gated channel alpha 2XCnga2<tm1Kob> targeted mutation 1, Reiko Kobayakawa
Frt yeast FRT (flippase recombination target) siteXFrt
Frt yeast FRT (flippase recombination target) siteXFrt
loxP phage P1 loxPXloxP
loxP phage P1 loxPXloxP
neo neomycin resistance gene (E. coli)X mouse phosphoglycerate kinase promoter (PGK promoter)
polyAX

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal sexual maturation(MP:0001937)

  • decreased aggression towards mice(MP:0003863)

  • increased fear-related response(MP:0003459)

  • reduced male mating frequency(MP:0001380)
  • Detailed phenotype data

    Ordering Information

    Donor DNAPhaga P1 loxP sites, yeast FRT (flipase recombination target) sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neomycin resistance gene, polyA, mouse Cyclic nucleotide-gated channel alpha 2 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 112(3):E311-20 (2015). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT shall contact the Developer scientist (Dr. Reiko Kobayakawa) and obtain a permission of its use.
    DepositorReiko Kobayakawa (Osaka Bioscience Institute)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Mar 2017

    BRC mice in Publications

    Fujimoto S, Leiwe MN, Aihara S, Sakaguchi R, Muroyama Y, Kobayakawa R, Kobayakawa K, Saito T, Imai T.
    Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice.
    Dev Cell (2023) 37290446