Strain Data Sheet

RBRC09305

Strain Information

Image
BRC No.RBRC09305
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Ciart<GT(IST11761C7)Tigm>/Taku
Former Common nameChrono KO, Ciart knockout
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
Goriki A, Hatanaka F, Myung J, Kim J K, Yoritaka T, Tanoue S, Abe T, Kiyonari H, Fujimoto K, Kato Y, Todo T, Matsubara A, Forger D, Takumi T
PLoS Biol. 12(4):e1001839, 2014 24736997

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ciart
MGI:2684975		circadian associated repressor of transcription3Ciart<GT(IST11761C7)Tigm>
MGI:4032237		gene trap IST11761C7, Texas A&M Institute for Genomic Medicine
LTR retrovirus LTR (viral long terminal repeat)3LTR
lacZ beta-galactosidase (E. coli)3
neo neomycin resistance gene (E. coli)3
SA (splice acceptor)3
SV40 polyA signal3

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • increased circulating corticosterone level(MP:0001745)

  • prolonged circadian behavior period(MP:0020469)
    • Detailed phenotype data

    Ordering Information

    Donor DNAretrovirus LTR (viral long terminal repeat), SA (splice acceptor), Bgeo (E. coli neo, E. coli lacZ), SV40 polyA, mouse Ciart genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT is requested to execute a MTA specified by TIGM. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorToru Takumi (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. TIGM_MTA
    5. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data