Strain Data Sheet

RBRC09309

Strain Information

Image
BRC No.RBRC09309
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Capn2<tm1Tcs>
Former Common nameCapn2 KO mouse
H-2 Haplotype
ES Cell lineNot specified (ES cell)
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.
Takano J, Mihira N, Fujioka R, Hosoki E, Chishti A H, Saido T C
Mol Cell Biol., (19):4097-106 (2011). 21791606

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Capn2
MGI:88264		calpain 21Capn2<tm1Tcs>
MGI:5292734		targeted mutation 1, Takaomi C. Saido
neo neomycin resistance gene (E. coli)1 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal blood circulation(MP:0002128)

  • abnormal vascular development(MP:0000259)

  • lethality throughout fetal growth and development, incomplete penetrance(MP:0011109)

  • pale placenta(MP:0004266)

  • prenatal lethality, complete penetrance(MP:0011091)
    • more 1 phenotypes
  • thin ventricular wall(MP:0000280)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, Mouse calpain-2 mutant genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell Biol., 19, 4097-4106 (2011).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTakaomi C. Saido (RIKEN CBS)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese/English)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data