Strain Data Sheet

RBRC09310

Strain Information

Image
BRC No.RBRC09310
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Cast<tm1Tcs>
Former Common nameCast KO mouse
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.
Takano J, Tomioka M, Tsubuki S, Higuchi M, Iwata N, Itohara S, Maki M, Saido T C
J. Biol. Chem., 280(16):16175-16184 (2005). 15691848

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cast
MGI:1098236		calpastatin13Cast<tm1Tcs>
MGI:3641275		targeted mutation 1, Takaomi C. Saido
  • peeling skin-leukonuchia-acral punctate keratoses-cheilitis-knuckle pads syndrome(MedGEN)
    • loxP phage P1 loxP13loxP
    SV40 polyadenylation signal13

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • increased susceptibility to neuronal excitotoxicity(MP:0008235)
    • Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage P1 loxP site, SV40 polyadenylation signal, mouse calpastatin mutant genome DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 280(16):16175-16184 (2005). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTakaomi C. Saido (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese/English)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data