Strain Data Sheet

RBRC09312

Strain Information

Image
BRC No.RBRC09312
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Hs6st2<tm1.1Kkm>
Former Common nameHS6ST-2 KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
6-O-sulfation of heparan sulfate differentially regulates various fibroblast growth factor-dependent signalings in culture.
Sugaya N, Habuchi H, Nagai N, Ashikari-Hada S, Kimata K
J. Biol. Chem., 283, 10366-10376 (2008). 18281280

Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.
Nagai N, Habuchi H, Sugaya N, Nakamura M, Imamura T, Watanabe H, Kimata K
Glycobiology, 23(8):980-992 (2013). 23690091

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Hs6st2
MGI:1354959		heparan sulfate 6-O-sulfotransferase 2XHs6st2<tm1.1Kkm>
MGI:3797642		targeted mutation 1.1, Koji Kimata
  • Paganini-Miozzo syndrome(MedGEN)
    • loxP phage P1 loxPXloxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Heparan sulfate 6-O-sulfotransferase-2 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorKoji Kimata (Aichi Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data