Strain Data Sheet

RBRC09314

Strain Information

Image
BRC No.RBRC09314
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameGpr98<tm1 (EYFP)>
Former Common nameVlgr1 EYFP knockin mice
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Vlgr1 knockout mice show audiogenic seizure susceptibility.
Yagi H, Takamura Y, Yoneda T, Konno D, Akagi Y, Yoshida K, Sato M
J Neurochem., 92, 191-202 (2005). 15606908

Vlgr1 is required for proper stereocilia maturation of cochlear hair cells.
Yagi H, Tokano H, Maeda M, Takabayashi T, Nagano T, Kiyama H, Fujieda S, Kitamura K, Sato M
Genes Cells., 12, 235-250 (2007). 17295842

Deficiency of Vlgr1 resulted in deafness and susceptibility to audiogenic seizures while the degree of hearing impairment was not correlated with seizure severity in C57BL/6- and 129-backcrossed lines of Vlgr1 knockout mice.
Yagi H, Noguchi Y, Kitamura K, Sato M
Neurosci. Lett., 461, 190-195 (2009). 19539720

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Adgrv1
MGI:1274784		adhesion G protein-coupled receptor V113Adgrv1<tm1> targeted mutation 1
  • febrile seizures, familial, 4(MedGEN)

  • Usher syndrome type 2C(MedGEN)
    • EYFP Enhanced Yellow Fluorescent Protein (Aequorea victoria)13EYFP
    neo neomycin resistance gene (E. coli)13 mouse phosphoglycerate kinase promoter (PGK promoter)
    SV40 polyA signal13

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal auditory cortex morphology(MP:0004631)

  • abnormal cochlear hair cell inter-stereocilial links morphology(MP:0004577)

  • abnormal femur compact bone thickness(MP:0013622)

  • abnormal outer hair cell stereociliary bundle morphology(MP:0004527)

  • absent cochlear ganglion(MP:0003146)
    • more 8 phenotypes
  • absent distortion product otoacoustic emissions(MP:0004737)

  • cochlear outer hair cell degeneration(MP:0004404)

  • decreased bone mass(MP:0004016)

  • decreased bone mineral density of femur(MP:0020010)

  • decreased femur stiffness(MP:0013638)

  • decreased trabecular bone volume(MP:0010879)

  • increased or absent threshold for auditory brainstem response(MP:0011967)

  • nonsyndromic hearing loss(MP:0004749)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Beta-galactosidase, E. coli Neomycin resistance gene, mouse phosphoglycerate kinase promoter (PGK promoter), Aequorea victoria Enhabced yellow fluorescent protein (EYFP) cDNA, SV40 polyadenylation signal, mouse Adgrv1 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurochem., 92, 191-202 (2005). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorMakoto Sato (University of Fukui)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data