Strain Data Sheet

RBRC09317

Strain Information

Image
BRC No.RBRC09317
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6CBA-B4galnt1<tm1Sia>/Kfk
Former Common namebeta 1.4GalNAc-T KO (GM2/GD2 synthase KO)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.
Takamiya K, Yamamoto A, Furukawa K, Yamashiro S, Shin M, Okada M, Fukumoto S, Haraguchi M, Takeda N, Fujimura K, Sakae M, Kishikawa M, Shiku H, Furukawa K, Aizawa S
Proc. Natl. Acad. Sci. USA, 93, 10662-10667 (1996). 8855236

Health Report

Examination Date / Room / Rack2024/05/27Room:4-BRack:JSentinel mouse program
2024/02/26Room:4-BRack:JSentinel mouse program
2023/11/27Room:4-BRack:JSentinel mouse program
2023/08/28Room:4-BRack:JSentinel mouse program
2023/05/29Room:4-BRack:JSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
B4galnt1
MGI:1342057		beta-1,4-N-acetyl-galactosaminyl transferase 110B4galnt1<tm1Sia>
MGI:2158348		targeted mutation 1, Shinichi Aizawa
  • hereditary spastic paraplegia 26(MedGEN)
    • neo neomycin resistance gene (E. coli)10 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal nervous system physiology(MP:0003633)

  • abnormal spermatogenesis(MP:0001156)

  • decreased nerve conduction velocity(MP:0008814)

  • neurodegeneration(MP:0002229)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE.coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), mouse B4galnt1 genomic DNA
    Research applicationDevelopmental Biology Research
    Metabolism Research
    Neurobiology Research
    Reproductive Biology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 93, 10662-10667 (1996). For profit use of the BIOLOGICAL RESSOURCE, the RECIPIENT must contact with the Intellectual Property Office, Nagoya University to obtain a prior written consent. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorKoichi Furukawa (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data