Strain Data Sheet

RBRC09330

Strain Information

Image
BRC No.RBRC09330
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameAngpt1(Acc.No.CDB0627K)
Former Common nameAngpt1(Acc.No.CDB0627K), Ang1<fl>, Ang1<flox>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Angiopoietin-1 guides directional angiogenesis through integrin alphavbeta5 signaling for recovery of ischemic retinopathy.
Lee J, Kim K E, Choi D K, Jang J Y, Jung J J, Kiyonari H, Shioi G, Chang W, Suda T, Mochizuki N, Nakaoka Y, Komuro I, Yoo O J, Koh G Y
Sci. Transl. Med., 5(203):203ra127 (2013). 24048525

Health Report

Examination Date / Room / Rack2024/11/18Room:4-ARack:KSentinel mouse program
2024/08/19Room:4-ARack:KSentinel mouse program
2024/05/20Room:4-ARack:KSentinel mouse program
2024/02/19Room:4-ARack:KSentinel mouse program
2023/11/20Room:4-ARack:KSentinel mouse program
2023/08/21Room:4-ARack:KSentinel mouse program
2023/05/22Room:4-ARack:KSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Angpt1
MGI:108448		angiopoietin 115Angpt1<tm1.1Yona>
MGI:5585457		targeted mutation 1.1, Yoshikazu Nakaoka
  • angioedema, hereditary, 5(MedGEN)
    • Frt yeast FRT (flippase recombination target) site15Frt
    loxP phage P1 loxP15loxP
    loxP phage P1 loxP15loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal choriocapillaris morphology(MP:0006238)

  • abnormal circulating insulin level(MP:0001560)

  • abnormal cone electrophysiology(MP:0004022)

  • abnormal retina cone cell morphology(MP:0001006)

  • decreased circulating insulin level(MP:0002727)
    • more 3 phenotypes
  • embryonic lethality(MP:0008762)

  • impaired glucose tolerance(MP:0005293)

  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast frt site, mouse Angpt1 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER Dr. Yoshikazu Nakaoka (National Cerebral and Cardiovascular Center )(ynakaoka@ncvc.go.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0627K and Web Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Sci Transl Med. 2013 5(203):203ra127.). (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data