Strain Data Sheet

RBRC09341

Strain Information

Image
BRC No.RBRC09341
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Il33<tm1Snak>
Former Common nameIL-33(Acc.No.CDB0631K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
IL-33 is a crucial amplifier of innate rather than acquired immunity.
Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S
Proc. Natl. Acad. Sci. USA, 107(43):18581-6 (2010). 20937871

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFPGreen Fluorescent Protein (Aequorea victoria)19
Il33interleukin 3319Il33targeted mutation 1, Susumu Nakae
loxPphage P1 loxP19loxP
loxPphage P1 loxP19loxP
neoneomycin resistance gene (E. coli)19mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • decreased airway responsiveness(MP:0002335)

  • decreased inflammatory response(MP:0001876)

  • decreased interleukin-1 alpha secretion(MP:0008655)

  • decreased interleukin-1 beta secretion(MP:0008658)

  • decreased interleukin-6 secretion(MP:0008706)
  • more 5 phenotypes
  • decreased susceptibility to endotoxin shock(MP:0008734)

  • decreased susceptibility to xenobiotic induced morbidity/mortality(MP:0009767)

  • immune system phenotype(MP:0005387)

  • increased susceptibility to induced colitis(MP:0008537)

  • lung inflammation(MP:0001861)
  • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neomycin resistance gene, jellyfish GFP cDNA, mouse Il33 genomic DNA
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Immunology and Inflammation Research
    Specific Term and Conditions(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0631K and Web Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Proc Natl Acad Sci U S A. 2010 107(43):18581-6.). (3) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data