Strain Data Sheet

RBRC09370

Strain Information

Image
BRC No.RBRC09370
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S6/SvEvtac-Epb4.1l2<tm1Tfur>
Former Common name4.1G KO
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain129S6/SvEvTac
Appearance
Strain development
Strain description
Colony maintenance
References
Protein-4.1G-Mediated Membrane Trafficking Is Essential for Correct Rod Synaptic Location in the Retina and for Normal Visual Function.
Sanuki R, Watanabe S, Sugita Y, Irie S, Kozuka T, Shimada M, Ueno S, Usukura J, Furukawa T
Cell Rep., 10, 796-808 (2015). 25660028

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Epb41l2
MGI:103009		erythrocyte membrane protein band 4.1 like 210Epb41l2<tm1Tfur>
MGI:5759995		targeted mutation 1, Takahisa Furukawa
neo neomycin resistance gene (E. coli)10 mouse phosphoglycerate kinase promoter (PGK promoter)
SV40 polyA signal10

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal b-wave implicit time(MP:0012039)

  • abnormal retina outer nuclear layer morphology(MP:0003731)

  • abnormal retina outer plexiform layer morphology(MP:0003732)

  • abnormal ribbon synapse morphology(MP:0020359)

  • abnormal visual contrast sensitivity(MP:0011831)
    • more 5 phenotypes
  • disorganized retina outer plexiform layer(MP:0008520)

  • increased b-wave implicit time(MP:0012150)

  • retina detachment(MP:0003099)

  • retina outer nuclear layer degeneration(MP:0008518)

  • thin retina outer plexiform layer(MP:0008519)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, SV40 polyadenylation site, mouse Epb4.1l2 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Reports, 10, 796-808 (2015).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
    DepositorTakahisa Furukawa (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data