Strain Data Sheet

RBRC09382

Strain Information

Image
BRC No.RBRC09382
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ndn<tm1Ky>
Former Common nameNecdin KO, C57BL/6, B6.Cg-Ndn<tm1Ky>(N20)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival.
Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, Okada M, Yoshikawa K
J. Neurosci., 25(30):7090-7099 (2005). 16049186

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ndn
MGI:97290		necdin, MAGE family member7Ndn<tm1Ky>
MGI:3586988		targeted mutation 1, Kazuaki Yoshikawa
neo neomycin resistance gene (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)
SV40 polyA signal7

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal dorsal root ganglion morphology(MP:0000961)

  • decreased body temperature(MP:0005534)

  • decreased circulating thyroid-stimulating hormone level(MP:0005119)

  • decreased circulating thyroxine level(MP:0005478)

  • decreased circulating triiodothyronine level(MP:0005479)
    • more 2 phenotypes
  • increased thermal nociceptive threshold(MP:0001973)

  • maternal imprinting(MP:0003122)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, SV40 Poly A signal, Mouse Ndn genomic DNA
    Research applicationDevelopmental Biology Research
    Mouse Models for Human Disease
    Neurobiology Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorKazuaki Yoshikawa (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data