Strain Data Sheet

RBRC09411

Strain Information

Image
BRC No.RBRC09411
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129.P-Zbtb7b<tm1.1Itan>
Former Common nameTHPOK-gfp reporter mice
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.
Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H, Taniuchi I
Nat. Immunol., 9, 1113-1121(2008). 18776907

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
EGFP Enhanced Green Fluorescent Protein (Aequorea victoria)3EGFP
Zbtb7b
MGI:102755		zinc finger and BTB domain containing 7B3Zbtb7b<tm1.1Itan> transgene insertion 1.1, Ichiro Taniuchi
loxP phage P1 loxP3loxP
polyA Simian virus 40 PolyA adenylation signal sequences3polyA

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal CD4-positive, alpha beta T cell morphology (MP:0002432)

  • abnormal CD4-positive, alpha-beta T cell physiology (MP:0005463)

  • absent CD4-positive, alpha-beta T cells (MP:0003790)

  • decreased CD4-positive, alpha-beta T cell number (MP:0008075)

  • increased CD8-positive, alpha-beta T cell number (MP:0008078)
    • more 1 phenotypes
  • increased double-negative T cell number (MP:0005090)
    • Detailed phenotype data

    Ordering Information

    Donor DNAAequorea victoria GFP, Enterrobacteria phage P1 LoxP site, Simian virus 40 PolyA adenylation signal sequences
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 9, 1113-1121(2008).
    DepositorIchiro Taniuchi (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data