Strain Data Sheet

RBRC09433

Strain Information

Image
BRC No.RBRC09433
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129(Cg)-Ick<tm1.1Tfur>
Former Common nameICK flox mice
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain129S6/SvEvTac
Appearance
Strain development
Strain description
Colony maintenance
References
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
Chaya T, Omori Y, Kuwahara R, Furukawa T
EMBO J., 33(11):1227-1242 (2014). 24797473

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site9Frt
Ick
MGI:1934157		intestinal cell kinase9Ick<tm1.1Tfur> targeted mutation 1, Takahisa Furukawa
  • endocrine-cerebro-osteodysplasia syndrome(DisGeNET, MedGEN)

  • epilepsy, juvenile myoclonic, susceptibility to, 10(MedGEN)
    • loxP phage P1 loxP9loxP
    loxP phage P1 loxP9loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal brain ependyma motile cilium morphology(MP:0011056)

  • abnormal cerebellum anterior lobe morphology(MP:0009960)

  • abnormal cochlear hair cell stereociliary bundle morphology(MP:0004521)

  • abnormal cochlear inner hair cell morphology(MP:0004393)

  • abnormal cochlear outer hair cell morphology(MP:0004399)
    • more 18 phenotypes
  • abnormal embryonic neuroepithelium primary cilium morphology(MP:0013213)

  • abnormal ependyma motile cilium morphology(MP:0011059)

  • abnormal organ of Corti morphology(MP:0000042)

  • abnormal organ of Corti supporting cell morphology(MP:0004300)

  • abnormal orientation of cochlear hair cell stereociliary bundles(MP:0004522)

  • cerebral arteriovenous malformation(MP:0010530)

  • decreased embryonic cilium length(MP:0011998)

  • decreased embryonic cilium number(MP:0013197)

  • decreased small intestinal villus size(MP:0008142)

  • decreased total retina thickness(MP:0011965)

  • enlarged brain ventricles(MP:0011380)

  • hydrocephaly(MP:0001891)

  • neonatal lethality, complete penetrance(MP:0011087)

  • preaxial polydactyly(MP:0009743)

  • pulmonary hypoplasia(MP:0001178)

  • respiratory failure(MP:0001953)

  • short limbs(MP:0000547)

  • small lung lobe(MP:0010976)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast FRT (flipase recombination target) site, mouse Ick genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 33(11):1227-1242(2014). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).　The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorTakahisa Furukawa (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityCurrently unavailable
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data