Strain Information | |
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Image | |
BRC No. | RBRC09525 |
Type | CRISPR/Cas9 (Transgene)![]() |
Species | Mus musculus |
Strain name | C57BL/6J-Ins1<em1(cre)Utr> |
Former Common name | I2AC mouse |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | |
Strain description | |
Colony maintenance | |
References | Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice. Yoshikazu Hasegawa, Yoshikazu Hoshino, Abdelaziz E Ibrahim, Kanako Kato, Yoko Daitoku, Yoko Tanimoto, Yoshihisa Ikeda, Hisashi Oishi, Satoru Takahashi, Atsushi Yoshiki, Ken-Ichi Yagami, Hiroyoshi Iseki, Seiya Mizuno, Fumihiro Sugiyama Exp. Anim., 65(3):319-27 (2016). 27053096 |
Health Report | |
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Examination Date / Room / Rack | 2024/05/20Room:4-ARack:CSentinel mouse program 2024/04/08Room:3-ARack:DSentinel mouse program 2024/02/19Room:4-ARack:CSentinel mouse program 2024/01/09Room:3-ARack:ASentinel mouse program 2023/11/20Room:4-ARack:CSentinel mouse program 2023/11/13Room:4-ARack:CAdditional tests 2023/10/10Room:3-ARack:ASentinel mouse program 2023/08/21Room:4-ARack:CSentinel mouse program 2023/08/07Room:4-ARack:CAdditional tests 2023/07/10Room:3-ARack:ASentinel mouse program 2023/05/22Room:4-ARack:CSentinel mouse program 2023/04/10Room:3-ARack:ASentinel mouse program |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
HBB2 | rabbit beta-globin polyA | 19 | HBB2 | ||||
Ins1 MGI:96572 | insulin I | 19 | Ins1<em1(cre)Utr> | endonuclease-induced mutation 1, University of Tsukuba Laboratory Animal Resource Center | |||
P2A | porcine teschovirus-1 2A peptide | 19 | P2A | ||||
cre | Phage P1 Cre recombinase | 19 | cre | ||||
nls | SV40 large T antigen nuclear localization signal (NLS) | 19 | nls |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | P2A (porcine teschovirus-1 2A peptide), Simian virus 40 nuclear localization signal (NLS), bacteriophage P1 Cre recombinase, rabbit beta globin polyA |
Research application | Cre/loxP system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) |
Depositor | Fumihiro Sugiyama (University of Tsukuba) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- Mouse of the Month Dec 2018 |
BRC mice in Publications |
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Lai S, Higuchi T, Tsuda M, Sugiyama Y, Morisawa K, Taniguchi T, Sakamoto S. NF90-NF45 is essential for β cell compensation under obesity-inducing metabolic stress through suppression of p53 signaling pathway. Sci Rep 12(1) 8837(2022) 35614067 |
Mostafa D, Yanagiya A, Georgiadou E, Wu Y, Stylianides T, Rutter GA, Suzuki T, Yamamoto T. Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation. Commun Biol 3(1) 476(2020) 32859966 |