Strain Data Sheet

RBRC09696

Strain Information

Image
BRC No.RBRC09696
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Former Common name#125
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Tetsuo Noda, The Cancer Institute of JFCR. C57BL/6J background.
Strain descriptionMice model for the lung adenocarcinoma. Transgenice mice expressing CD74-ROS1 fusion protein under the control of the human SPC promoter.
Colony maintenance
References
Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency.
Inoue M, Toki H, Matsui J, Togashi Y, Dobashi A, Fukumura R, Gondo Y, Minowa O, Tanaka N, Mori S, Takeuchi K, Noda T
Carcinogenesis, 37, 452-460 (2016). 26964870

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
CD74 CD74 antigen (human)UNCD74 human SFTPC promoter
FLAG FLAG tag (synthetic)UNFLAG
ROS1 Ros1 proto-oncogene (human)UNROS1

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • increased lung adenocarcinoma incidence(MP:0002027)

  • increased lung adenoma incidence(MP:0002048)

  • increased lung non-small cell carcinoma incidence(MP:0008716)

  • increased lung tumor incidence(MP:0008014)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman SFTPC promoter, Flag tag (synthetic), human CD74 cDNA, human ROS1 cDNA, SV40 Splicing and Poly(A)
    Research applicationCancer Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Carcinogenesis, 37, 452-460 (2016). For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorTetsuo Noda (Japanese Foundation For Cancer Research)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data