Strain Data Sheet

RBRC09819

Strain Information

Image
BRC No.RBRC09819
TypeConsomic
SpeciesMus musculus
Strain nameICGN-Chr2<B6>
Former Common nameICGN-Chr 2B6
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Nobuya Sasaki, Hokkaido University in 2014.
Strain descriptionThis consomic line in the ICGN background carries the chromosome 2 derived from B6. This line is useful to study nephrosis.
Colony maintenance
References
Mouse chromosome 2 harbors genetic determinants of resistance to podocyte injury and renal tubulointerstitial fibrosis.
Sasaki H, Kimura J, Nagasaki K, Marusugi K, Agui T, Sasaki N
BMC Genet., 17(1):69 (2016). 27230548

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal renal glomerulus morphology(MP:0005325)

  • albuminuria(MP:0002871)

  • anemia(MP:0001577)

  • decreased hematocrit(MP:0000208)

  • decreased hemoglobin content(MP:0002874)
    • more 3 phenotypes
  • decreased urine albumin level(MP:0005540)

  • expanded mesangial matrix(MP:0011353)

  • tubulointerstitial nephritis(MP:0011405)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. Depending on the content of the research, the DEPOSITOR may request collaboration.
    DepositorNobuya Sasaki (Kitasato University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data