Strain Data Sheet

RBRC09897

Strain Information

Image
BRC No.RBRC09897
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(EIF1AX-Aldh2<*>E504K)101Oht
Former Common nameDAL101 mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Shigeo Ohta, Nippon Medical School in 2009. A transgenic construct was injected into fertilized eggs derived from C57BL/6. This line was maintained in C57BL/6N background.
Strain descriptionTransgenic mice overexpressing mutated Aldh2 (E504K) under the control of the human EF1a promoter. This mutated Aldh2 acts in a dominant-negative manner.
Colony maintenance
ReferencesJ. Neurosci., 28, 6239-6249 (2008). 18550766

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Aldh2aldehyde dehydrogenase 2, mitochondrialUNAldh2human elongation factor 1 alpha (EF-1 alpha) promoter

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
human G-CSF cDNA PolyA signalUN

Ordering Information

Donor DNAMouse 改変型ALDH2,Human G-CSF cDNA PolyA signal, Human EF1a promoter
Research applicationNeurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 6239-6249 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorShigeo Ohta (Nippon Medical School)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data