Strain Data Sheet
RBRC09995
Strain Information | |
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| Image | |
| BRC No. | RBRC09995 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6.Cg-Mapt<tm1.1(MAPT)Tcs> |
| Former Common name | hTau KI mouse |
| H-2 Haplotype | |
| ES Cell line | iTL BA1 [C57BL/6N Tac x 129S6/SvEvTac] |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Nat. Commun., 10(1):2394 (2019). 31160584 J. Biol. Chem., 294(34):12754-12765 (2019). 31273083 |
Health Report | |
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| Examination Date / Room / Rack | 2024/01/09Room:3-ARack:G 2023/10/16Room:3-ARack:G 2023/10/10Room:3-ARack:G 2023/07/10Room:3-ARack:G 2023/04/10Room:3-ARack:G 2023/02/13Room:3-ARack:G 2023/01/10Room:3-ARack:G 2022/10/11Room:3-ARack:G 2022/07/11Room:3-ARack:G |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site11Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter MAPTmicrotubule-associated protein tau (human)11MAPT Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP11loxP |
Ordering Information | |
|---|---|
| Donor DNA | human MAPT genomic DNA, yeast FRT site, Phage P1 loxP site, mouse Mapt genomic DNA |
| Research application | Cre/loxP system FLP/frt system |
| Specific Term and Conditions | The BIOLOGICAL RESOURCE is the property of the RIKEN (The Institute of Physical and Chemical Research). RECIPIENT agrees to acknowledge Shoko HASHIMOTO, Takashi SAITO and Takaomi C. SAIDO in an acknowledgement section. RECIPIENT also agrees to cite Nature Communications 10: 2394 (2019) and Journal of Biological Chemistry, 294: 12754-12765 (2019) in all publications obtained using BIOLOGICAL RESOURCE. RECIPIENT agrees to acknowledge DEPOSITOR in all oral presentations and written publications as related to the BIOLOGICAL RESOURCE. RECIPIENT shall keep confidential any or all information marked CONFIDENTIAL that is received from DEPOSITOR and related to the BIOLOGICAL RESOURCE including oral discussions if they are reduced to writing within thirty (30) days and are marked "CONFIDENTIAL". For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR (takaomi.saido@riken.jp) and must obtain a prior written consent from the DEPOSITOR. If any invention is conceived and reduced to practice by RECIPIENT in the performance of the Research Plan involving the BIOLOGICAL RESOURCE during the term of this MTA, RECIPIENT agrees to promptly inform the invention to DEPOSITOR and the parties will consult each other to determine inventorship and ownership of the invention based on the respective parties contribution to the invention, before filing an application for a patent. In the case of a jointly owned application, the parties will separately enter into a joint application agreement including the sharing of ownership, patent costs and licensing income, as well as the responsible party for the application procedures etc. |
| Depositor | Takaomi C. Saido (RIKEN CBS) |
| Strain Status |  Live mice Frozen embryos Frozen sperm |
| Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Wakako Kumita, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido Recent Advances in the Modeling of Alzheimer’s Disease Frontiers Neuroscience 16 (2022) 35431779 |