Strain Data Sheet

RBRC10020

Strain Information

Image
BRC No.RBRC10020
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Myh6-Kcnj8<*>S422L)105Hnky
Former Common nameKir6.1-TGmt#105
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Haruaki Nakaya, Chiba University. C57BL/6 genetic background. Next generation should be obtained by crossing TG males to wild-type females.
Strain descriptionTransgenic mice expressing rat mutated Kcnj8 (S422L) under the control of mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter.
Colony maintenance
References
Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy.
Watanabe Y, Kishimoto T, Miki T, Seino S, Nakaya H, Matsumoto A
Sci. Rep., 8(1):11723 (2018). 30082733

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GH Growth hormone polyA (human)UNGH
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 (rat)UNKcnj8 mouse Myh6 promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal R wave(MP:0011919)

  • abnormal ST segment(MP:0003897)

  • abnormal action potential(MP:0005402)

  • abnormal heart electrocardiography waveform feature(MP:0010508)

  • abnormal myocardial fiber currents(MP:0020345)
    • more 3 phenotypes
  • cardiac fibrosis(MP:0003141)

  • mortality/aging(MP:0010768)

  • prolonged QT interval(MP:0003233)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse (APH)II MyHC promoter, Rat KCNJ8 cDNA(C420N, P421T, S422L), human GH polyA
    Research applicationCardiovascular Research
    Diabetes and Obesity Research
    covid19_progression
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorHaruki Nakaya (Chiba University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data