Strain Data Sheet

RBRC10024

Strain Information

Image
BRC No.RBRC10024
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Ly6a-APOBEC3B<*>v1)7Fscr
Former Common nameA3B Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Hiroaki Honda at Hiroshima University and Taeko Wada at Jichi Medical University in 2016. C57BL/6 genetic background.
Strain descriptionTransgenic mice expressing human APOBEC3B under the control of mouse Ly6a promoter. RBRC10024 is Line 7.
Colony maintenance
References
APOBEC3B is an enzymatic source of mutation in breast cancer.
Burns M B, Lackey L, Carpenter M A, Rathore A, Land A M, Leonard B, Refsland E W, Kotandeniya D, Tretyakova N, Nikas J B, Yee D, Temiz N A, Donohue D E, McDougle R M, Brown W L, Law E K, Harris R S
Nature, 494, 366-370 (2013). 23389445

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (human)UNAPOBEC3B mouse Ly6a promoter
SV40 polyA signalUN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Sca-1(Ly6A) promoter, human APOBEC3B gene cDNA, SV40 PolyA signal
    Research applicationCancer Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorYusuke Furukawa (Jichi Medical University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data