Strain Data Sheet

RBRC10047

Strain Information

Image
BRC No.RBRC10047
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6(D2)-Sufu<Rgsc2070>
Former Common nameSufuS157R
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by RIKEN ENU-based gene-driven mutagenesis. Mice were backcrossed to C57BL/6J over 15 generations. Y chromosome is derived from C57BL/6J. Both homozygous and heterozygous mutants show no obvious phenotype.
Strain descriptionMutant mouse strain established by RIKEN ENU-based gene-driven mutagenesis. Gene: Sufu [suppressor of fused homolog (Drosophila)]: C→A Type: Ser157Arg.
Colony maintenance
References
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Gondo Y
Nat. Rev. Genet., 9 (10), 803-810 (2008). 18781157

T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.
Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui C C, Gondo Y
PLoS One, 10(3):e0119455 (2015). 25760946

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sufu
MGI:1345643		SUFU negative regulator of hedgehog signaling19Sufu<Rgsc2070> RIKEN Genomic Sciences Center (GSC), 2070
  • familial meningioma(MedGEN)

  • Joubert syndrome 32(MedGEN)

  • medulloblastoma(DisGeNET, MedGEN)
    • more 1 Diseases
  • nevoid basal cell carcinoma syndrome(DisGeNET, MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationCancer Research
    Developmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455.
    DepositorYoichi Gondo (RIKEN GSC)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data