Strain Data Sheet

RBRC10097

Strain Information

Image
BRC No.RBRC10097
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;Cg-Dach1<tm1.2Hhsk>
Former Common nameDach-conditional KO
H-2 Haplotype
ES Cell lineKY1.1[(C57BL/6J x 129S6/SvEvTac)F1]
Background strain
Appearance
Strain developmentDeveloped by Haruko Hayasaka, Kindai University. KY1.1 ES cells derived from (C57BL/6J x 129S6/SvEvTac)F1. Mixed genetic background.
Strain descriptionDachshund1 (Dach1) flox mouse. A pair of loxP sites flank exon 1. The Neo cassette was removed by crossing with a Flp mouse line.
Colony maintenance
References
Dach1 is essential for maintaining normal mature podocytes.
Keiko Tanaka, Haruko Hayasaka, Taiji Matsusaka
PLoS One, 19(5):e0303910 (2024). 38805434

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dach1
MGI:1277991		dachshund family transcription factor 114Dach1<tm1.2Hhsk> targeted mutation 1.2, Haruko Hayasaka
Frt yeast FRT (flippase recombination target) site14Frt
loxP phage P1 loxP14loxP
loxP phage P1 loxP14loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast FRT (flipase recombination target) site, mouse Dach1 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER, Dr. Haruko Hayasaka (hhayasaka@life.kindai.ac.jp) using the Approval Form. RECIPIENT, which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research, is required to enter into a Material Transfer Agreement with Kindai University.
    DepositorHaruko Hayasaka (Kindai University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data