Strain Data Sheet

RBRC10155

update : 2025-02-20

Strain Information
Image
BRC No.	RBRC10155
Type	Targeted Mutation
Species	Mus musculus
Strain name	Ccdc141(Acc.No.CDB0658K)
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References	Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. Fukuda T, Nagashima S, Abe T, Kiyonari H, Inatome R, Yanagi S EMBO Rep., 17(12):1785-1798 (2016). 27737934

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
Ccdc141 MGI:1919735	coiled-coil domain containing 141	2	Ccdc141<tm1Ygi> MGI:6148228	targeted mutation 1, Shigeru Yanagi			hypogonadotropic hypogonadism 7 with or without anosmia(MedGEN)
Frt	yeast FRT (flippase recombination target) site	2	Frt
loxP	phage P1 loxP	2	loxP
neo	neomycin resistance gene (E. coli)	2				mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype
Annotation by Mammalian phenotyhpe ontology	abnormal innervation(MP:0002184) abnormal neuronal migration(MP:0006009) abnormal response to novel object(MP:0003461) behavior/neurological phenotype(MP:0005386) behavioral despair(MP:0002573) more 8 phenotypes decreased grooming behavior(MP:0001442) decreased thermal nociceptive threshold(MP:0003998) growth/size/body region phenotype(MP:0005378) hyperactivity(MP:0001399) increased anxiety-related response(MP:0001363) mortality/aging(MP:0010768) nervous system phenotype(MP:0003631) reproductive system phenotype(MP:0005389)
Detailed phenotype data

Annotation by Mammalian phenotyhpe ontology

abnormal innervation(MP:0002184)

abnormal neuronal migration(MP:0006009)

abnormal response to novel object(MP:0003461)

behavior/neurological phenotype(MP:0005386)

behavioral despair(MP:0002573)

more 8 phenotypes

decreased grooming behavior(MP:0001442)

decreased thermal nociceptive threshold(MP:0003998)

growth/size/body region phenotype(MP:0005378)

hyperactivity(MP:0001399)

increased anxiety-related response(MP:0001363)

mortality/aging(MP:0010768)

nervous system phenotype(MP:0003631)

reproductive system phenotype(MP:0005389)

Detailed phenotype data

Ordering Information
Donor DNA	E. coli Neo, Phage P1 loxP, yeast frt, PGK promoter, mouse PGK3' end
Research application	Cre/loxP system FLP/frt system
Specific Term and Conditions	In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO Rep., 17(12):1785-1798 (2016).(1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER (Dr. Shigeru Yanagi (syanagi@ls.toyaku.ac.jp)) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0658K) and Web Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (EMBO Rep., 17(12):1785-1798 (2016).) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
Depositor	RIKEN CDB (RIKEN CDB)
Strain Status	Frozen embryos
Strain Availability	Recovery and QC required prior to distribution
Additional Info.	Necessary documents for ordering: Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data