Strain Information | |
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Image | |
BRC No. | RBRC10208 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Src<tm1(S75D)Goka> |
Former Common name | SrcS75D, SrcSD |
H-2 Haplotype | |
ES Cell line | CCE [129/Sv] |
Background strain | |
Appearance | |
Strain development | Developed by Goro Kato, University of Yamanashi in 2001. CCE ES cells derived from 129/SvEv were used. C57BL/6 congenic strain by backcrossing to C57BL/6N for 6 generations. |
Strain description | Mutant mice in which a point mutation in the Src gene was introduced at Serine 75 to convert it to Aspartic acid (S75D). |
Colony maintenance | |
References | Production of mouse ES cells homozygous for Cdk5-phosphorylated site mutation in c-Src alleles. Kato G, Maeda S J. Biochem., 133, 563-569 (2003). 12801906A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice. Kashiwagi K, Ito S, Maeda S, Kato G Sci. Rep., 7, 16779 (2017). 29196663 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Src | Rous sarcoma oncogene | 2 | Src | targeted mutation 1, Goro Kato |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse Src genomic DNA (S75D mutant) |
Research application | |
Specific Term and Conditions | In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Goro Kato (University of Yamanashi) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |