Strain Data Sheet

RBRC10231

Strain Information

Image
BRC No.RBRC10231
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.129S6-Bcl2l12/Irf3<tm1Ttg>
Former Common nameC.129S6-Bcl2l12/Irf3<tm1Ttg>
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeveloped and deposited by Dr. Steven N. Emancipator, Case Western Reserve University in 2018.
Strain descriptionIrf3 deficient mice. This is a BABL/c congenic strain by crossing RBRC00858 (B6;129S6-Bcl2l12/Irf3<tm1Ttg>/TtgRbrc) to BABL/cJ for 14 generations.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bcl2l12
MGI:1922986		BCL2 like 127Bcl2l12<tm1Ttg>
MGI:4353426		targeted mutation 1, Tadatsugu Taniguchi
Irf3
MGI:1859179		interferon regulatory factor 37Irf3<tm1Ttg>
MGI:3577601		targeted mutation 1, Tadatsugu Taniguchi
  • herpes simplex encephalitis, susceptibility to, 7(MedGEN)
    • neo neomycin resistance gene (E. coli)7 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating interferon level(MP:0008548)

  • decreased cellular sensitivity to ultraviolet irradiation(MP:0008411)

  • increased susceptibility to viral infection(MP:0002418)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse IRF-3 genomic DNA, mouse Bcl2l12 genomic DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURSE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURSE.
    DepositorSteven N. Emancipator (Case Western Reserve University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data