Strain Data Sheet

RBRC10237

update : 2025-02-20

Strain Information
Image
BRC No.	RBRC10237
Type	Targeted Mutation Congenic
Species	Mus musculus
Strain name	B6.Cg-Stx1a<tm1Tfuj>/712
Former Common name	Syntaxin1A (or HPC-1)
H-2 Haplotype
ES Cell line	TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development	Developed by Tomonori Fujiwara, Kyorin University in 2013. TT2 ES cells were used. Mice were backcrossed to C57BL/6J for 9 generations. This strain was derived from ES clone #712.
Strain description	Stx1a [syntaxin 1A (brain)] knockout mice.
Colony maintenance
References	Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity. Fujiwara T, Mishima T, Kofuji T, Chiba T, Tanaka K, Yamamoto A, Akagawa K J. Neurosci. May 26 (21) 5767-5776. (2006). 16723534

Health Report
Examination Date / Room / Rack

Gene
Gene Symbol	Gene Name	Chr.	Allele Symbol	Allele Name	Common Names	Promoter	Diseases Related to This Gene
GH	Growth hormone polyA (Bovine)	5	GH
Stx1a MGI:109355	syntaxin 1A (brain)	5	Stx1a<tm1Tfuj> MGI:3629049	targeted mutation 1, Tomonori Fujiwara
neo	neomycin resistance gene (E. coli)	5				herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype
Annotation by Mammalian phenotyhpe ontology	abnormal cued conditioning behavior(MP:0001454) abnormal excitatory postsynaptic potential(MP:0002912) abnormal hypothalamus secretion(MP:0001752) abnormal latent inhibition of conditioning behavior(MP:0006299) abnormal nervous system physiology(MP:0003633) more 6 phenotypes abnormal response to novel object(MP:0003461) abnormal social investigation(MP:0001360) increased serotonin level(MP:0010069) increased startle reflex(MP:0001488) mortality/aging(MP:0010768) reduced long-term potentiation(MP:0001473)
Detailed phenotype data

Annotation by Mammalian phenotyhpe ontology

abnormal cued conditioning behavior(MP:0001454)

abnormal excitatory postsynaptic potential(MP:0002912)

abnormal hypothalamus secretion(MP:0001752)

abnormal latent inhibition of conditioning behavior(MP:0006299)

abnormal nervous system physiology(MP:0003633)

more 6 phenotypes

abnormal response to novel object(MP:0003461)

abnormal social investigation(MP:0001360)

increased serotonin level(MP:0010069)

increased startle reflex(MP:0001488)

mortality/aging(MP:0010768)

reduced long-term potentiation(MP:0001473)

Detailed phenotype data

Ordering Information
Donor DNA	herpes simplex virus thymidine kinase promoter (MC1 promoter), E. coli neo, Bovine growth hormone polyA, mouse HPC-1/syntaxin1A genome DNA
Research application
Specific Term and Conditions	Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci. May 26 (21) 5767-5776. (2006).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Depositor	Tomonori Fujiwara (Kyorin University)
Strain Status	Frozen sperm
Strain Availability	Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month)
Additional Info.	Necessary documents for ordering: Approval form (Japanese / English) Order form (Japanese / English) Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English) Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data