Strain Data Sheet

RBRC10255

Strain Information

Image
BRC No.RBRC10255
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC.B6-Il17rb<tm1Tgi>
Former Common nameIL17RB KO
H-2 Haplotype
ES Cell line
Background strainBALB/cAnNCrlCrlj
Appearance
Strain developmentDeveloped by Masaru Taniguchi, RIKEN Center for Integrative Medical Sciences in 2012. B6JN/1 ES cells were used. This line was backcrossed with BALB/c more than 8 generations.
Strain descriptionIl17rb (interleukin 17 receptor B) knockout mice.
Colony maintenance
References
Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines.
Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M
PLoS Biol., 10(2), e1001255 (2012). 22346732

Health Report

Examination Date / Room / Rack2023/05/08Room:2-検Rack:FSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Il17rb
MGI:1355292		interleukin 17 receptor B14Il17rb<tm1Tgi>
MGI:5426267		targeted mutation 1, Masaru Taniguchi
loxP phage P1 loxP14loxP
loxP phage P1 loxP14loxP
neo neomycin resistance gene14 mouse phosphoglycerate kinase promoter (PGK promoter)
SV40 polyA14

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal interleukin secretion(MP:0008568)

  • decreased NK T cell number(MP:0008040)

  • decreased airway responsiveness(MP:0002335)

  • decreased interleukin-10 secretion(MP:0008661)

  • decreased interleukin-13 secretion(MP:0008673)
    • more 5 phenotypes
  • decreased interleukin-17 secretion(MP:0008682)

  • decreased interleukin-5 secretion(MP:0008703)

  • decreased interleukin-9 secretion(MP:0008712)

  • decreased susceptibility to induced colitis(MP:0008539)

  • decreased susceptibility to weight loss(MP:0010181)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, mouse PGK promoter, E. coli neomycin resistance gene, SV40 Poly A, mouse Il17rb genomic DNA
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS Biol. 10(2), e1001255, (2012).
    DepositorMasaru Taniguchi (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data