Strain Data Sheet

RBRC10273

Strain Information

Image
BRC No.RBRC10273
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Myh6-Bdh1)1Smat
Former Common nameBdh1-Tg mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Satoaki Matoba, Kyoto Prefectural University of Medicine. C57BL/6J genetic background.
Strain descriptionTransgenic mice expressing Bdh1(3-hydroxybutyrate dehydrogenase, type 1)under the control of mouse αMHC promoter.
Colony maintenance
References
Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload-Induced Heart Failure.
Uchihashi M, Hoshino A, Okawa Y, Ariyoshi M, Kaimoto S, Tateishi S, Ono K, Yamanaka R, Hato D, Fushimura Y, Honda S, Fukai K, Higuchi Y, Ogata T, Iwai-Kanai E, Matoba S
Circ Heart Fail., 10(12) 1-11 (2017). 29242353

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bdh1 3-hydroxybutyrate dehydrogenase, type 1UNBdh1

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal DNA-templated transcription(MP:0020845)

  • cardiac fibrosis(MP:0003141)

  • congestive heart failure(MP:0006138)

  • decreased apoptosis(MP:0006043)

  • decreased response of heart to induced stress(MP:0004486)
    • more 4 phenotypes
  • dilated heart left ventricle(MP:0002753)

  • increased cellular sensitivity to DNA damaging agents(MP:0014040)

  • increased cellular sensitivity to oxidative stress(MP:0008412)

  • myocardium hypertrophy(MP:0010633)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Myh7 3‘UTR (myosin, heavy polypeptide 7, cardiac muscle, beta), mouse Myh6 promoter (myosin, heavy polypeptide 6, cardiac muscle, alpha), mouse Bdh1 (3-hydroxybutyrate dehydrogenase, type 1) cDNA, human GH polyA (human growth hormone)
    Research applicationCardiovascular Research
    Metabolism Research
    covid19_progression
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorSatoaki Matoba (Kyoto Prefectural University of Medicine)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data