Strain Data Sheet

RBRC10292

Strain Information

Image
BRC No.RBRC10292
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Itpr1<tm1.1Kmik>/274D Itpr2<tm2.1Kmik> Itpr3<tm2.1Kmik>
Former Common nameTriple Itpr floxed mice, Itpr1,2,3fl/fl mice, Accession No. CDB0841K, Accession No. CDB0841K
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Katsuhiko Mikoshiba, RIKEN Brain Science Institute in 2018.
Strain descriptionFloxed mice for three genes in Itpr family, Itpr1, Itpr2 and Itpr3.
Colony maintenance
References
Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice.
Sugawara T, Hisatsune C, Le T D, Hashikawa T, Hirono M, Hattori M, Nagao S, Mikoshiba K
J. Neurosci., 33(30) 12186-12196 (2013). 23884927

Health Report

Examination Date / Room / Rack2024/12/09Room:3-5Rack:CSentinel mouse program
2024/09/09Room:3-5Rack:CSentinel mouse program
2024/06/10Room:3-5Rack:CSentinel mouse program
2024/03/11Room:3-5Rack:CSentinel mouse program
2023/12/11Room:3-5Rack:CSentinel mouse program
2023/09/11Room:3-5Rack:CSentinel mouse program
2023/06/13Room:3-5Rack:CSentinel mouse program
2023/05/22Room:3-5Rack:CAdditional tests
2023/03/13Room:3-5Rack:CSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site17Frt
Itpr3
MGI:96624		inositol 1,4,5-triphosphate receptor 317Itpr3<tm2.1Kmik> targeted mutation 2.1, Katsuhiko Mikoshiba
  • type 1 diabetes mellitus(MedGEN)
    • loxP phage P1 loxP17loxP
    loxP phage P1 loxP17loxP
    Frt yeast FRT (flippase recombination target) site6Frt
    Itpr1
    MGI:96623    		inositol 1,4,5-trisphosphate receptor 16Itpr1<tm1.1Kmik>
    MGI:5532199    		targeted mutation 1.1, Katsuhiko Mikoshiba
  • aniridia-cerebellar ataxia-intellectual disability syndrome(MedGEN)

  • obsolete spinocerebellar ataxia type 16(MedGEN)

  • spinocerebellar ataxia type 29(MedGEN)
    • Itpr2
    MGI:99418    		inositol 1,4,5-triphosphate receptor 26Itpr2<tm2.1Kmik> targeted mutation 2.1, Katsuhiko Mikoshiba
  • isolated anhidrosis with normal sweat glands(MedGEN)
    • loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, yeast FRT (flipase recombination target) sites, mouse Itpr1 genomic DNA, mouse Itpr2 genomic DNA, mouse Itpr3 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKatsuhiko Mikoshiba (RIKEN)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data