Strain Data Sheet

RBRC10297

Strain Information

Image
BRC No.RBRC10297
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Itpr1<tm1.1Kmik>/75F
Former Common nameItpr1 floxed mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Katsuhiko Mikoshiba, RIKEN Brain Science Institute in 2013. ES cells derived from 129S/SvEv were used. This strain was backcrossed to C57BL/6 for 9 generations. This is derived from ES clone #75F.
Strain descriptionItpr1 (inositol 1,4,5-trisphosphate receptor 1) floxed mice. A neo gene fragment was removed.
Colony maintenance
References
Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice.
Sugawara T, Hisatsune C, Le T D, Hashikawa T, Hirono M, Hattori M, Nagao S, Mikoshiba K
J. Neurosci., 33(30) 12186-12196 (2013). 23884927

Health Report

Examination Date / Room / Rack2024/11/18Room:4-ARack:KSentinel mouse program
2024/08/19Room:4-ARack:KSentinel mouse program
2024/05/20Room:4-ARack:KSentinel mouse program
2024/02/19Room:4-ARack:KSentinel mouse program
2023/11/20Room:4-ARack:KSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itpr1
MGI:96623		inositol 1,4,5-trisphosphate receptor 16Itpr1<tm1.1Kmik>
MGI:5532199		targeted mutation 1.1, Katsuhiko Mikoshiba
  • aniridia-cerebellar ataxia-intellectual disability syndrome(MedGEN)

  • obsolete spinocerebellar ataxia type 16(MedGEN)

  • spinocerebellar ataxia type 29(MedGEN)
    • loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse Itpr1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKatsuhiko Mikoshiba (RIKEN)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityLive mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data