Strain Data Sheet

RBRC10318

Strain Information

Image
BRC No.RBRC10318
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;Cg-Kat5<tm1.1Hko>
Former Common nameTip60
H-2 Haplotype
ES Cell lineM1 [(C57BL/6 x 129)F1]
Background strainC57BL/6NCrl
Appearance
Strain developmentDeveloped by Haruhiko Koseki, RIKEN and Issay Kitabayash, National Cancer Center Research Institute in 2013. M1 ((129 x C57BL/6)F1) ES cells were used. This strain was backcrossed to C57BL/6J twice. A neo cassette was removed by crossing a Flp mouse strain.
Strain descriptionKat5 (K(lysine) acetyltransferase 5) flox mouse. A pair of loxP flank exon 10 and 11 of the Kat5.
Colony maintenance
References
EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.
Dong Y, Isono K I, Ohbo K, Endo T A, Ohara O, Maekawa M, Toyama Y, Ito C, Toshimori K, Helin K, Ogonuki N, Inoue K, Ogura A, Yamagata K, Kitabayashi I, Koseki H
Mol. Cell. Biol., 37(19), e00082-17 (2017). 28694333

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site19Frt
Kat5
MGI:1932051
K(lysine) acetyltransferase 519Kat5<tm1.1Hko> targeted mutation 1.1, Haruhiko Koseki
  • neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities(MedGEN)
  • loxP phage P1 loxP19loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal prostate gland morphology(MP:0001158)

  • abnormal testis morphology(MP:0001146)

  • seminiferous tubule degeneration(MP:0001154)

  • small testis(MP:0001147)
  • Detailed phenotype data

    Ordering Information

    Donor DNA酵母 FRT配列, バクテリオファージP1 loxP
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHaruhiko Koseki (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data