Strain Data Sheet

RBRC10369

Strain Information

Image
BRC No.RBRC10369
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6.ICGN-Tns2<nph>
Former Common nameB6-Tns2nph
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Nobuya Sasaki, Hokkaido University in 2010. C57BL/6J x ICGN F1 was backcrossed to C57BL/6J over 10 generations and then homozygous Tns2<nph> mutation was maintained by sister-brother mating. Y chromosome is derived from C57BL/6J.
Strain descriptionC57BL/6J congenic line harboring Tensin2 mutation (Tns2<nph>) derived from the ICGN strain. This line is useful to study nephrosis.129 backgound (RBRC10049), B6J backgound (RBRC10369), FVB background (RBRC10370)
Colony maintenance
References
Genetic background strongly influences the severity of glomerulosclerosis in mice.
Nishino T, Sasaki N, Nagasaki K, Ahmad Z, Agui T
J. Vet. Med. Sci., 72(10),1313-1318.(2010). 20484839

The 129 genetic background affects susceptibility to glomerulosclerosis in tensin2-deficient mice.
Nishino T, Sasaki N, Nagasaki K, Ichii O, Kon Y, Agui T
Biomed. Res., 33, 53-56 (2012). 22361887

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tns2
MGI:2387586		tensin 215Tns2<nph>
MGI:2447990		tensin 2; nephrosis

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal renal glomerulus basement membrane thickness(MP:0011349)

  • abnormal renal glomerulus morphology(MP:0005325)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationMouse Models for Human Disease
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. Depending on the content of the research, the DEPOSITOR may request collaboration.
    DepositorNobuya Sasaki (Kitasato University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data