Strain Data Sheet

RBRC10370

Strain Information

Image
BRC No.RBRC10370
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameFVB.ICGN-Tns2<nph>
Former Common name
H-2 Haplotype
ES Cell line
Background strainFVB/NJcl
Appearance
Strain developmentDeveloped by Nobuya Sasaki, Hokkaido University in 2010. C57BL/6J x ICGN F1 was backcrossed to FVB over 10 generations. Y chromosome is derived from FVB.
Strain descriptionFVB congenic line harboring Tensin2 mutation (Tns2<nph>) derived from the ICGN strain. This line is useful to study nephrosis. Homozygous mutants develop albuminuria, renal fibrosis and renal anemia as seen in ICGN mice. The mutants also demonstrated podocyte foot process alteration.
Colony maintenance
References
The 129 genetic background affects susceptibility to glomerulosclerosis in tensin2-deficient mice.
Nishino T, Sasaki N, Nagasaki K, Ichii O, Kon Y, Agui T
Biomed. Res., 33, 53-56 (2012). 22361887

Genetic background-dependent diversity in renal failure caused by the tensin2 gene deficiency in the mouse.
Sasaki H, Marusugi K, Kimura J, Kitamura H, Nagasaki K, Torigoe D, Agui T, Sasaki N
Biomed. Res., 36(5), 323-330 (2015). 26522149

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tns2
MGI:2387586		tensin 215Tns2<nph>
MGI:2447990		tensin 2; nephrosis

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal glomerular capillary morphology(MP:0011320)

  • abnormal glomerular mesangium morphology(MP:0011339)

  • abnormal kidney morphology(MP:0002135)

  • abnormal podocyte foot process morphology(MP:0008059)

  • abnormal podocyte morphology(MP:0005326)
    • more 18 phenotypes
  • abnormal renal glomerulus morphology(MP:0005325)

  • albuminuria(MP:0002871)

  • anemia(MP:0001577)

  • decreased circulating total protein level(MP:0005567)

  • decreased hematocrit(MP:0000208)

  • dilated renal tubule(MP:0002705)

  • edema(MP:0001785)

  • fused podocyte foot processes(MP:0008139)

  • glomerulosclerosis(MP:0005264)

  • increased blood urea nitrogen level(MP:0005565)

  • increased circulating cholesterol level(MP:0005178)

  • increased renal glomerulus basement membrane thickness(MP:0011409)

  • increased urine protein level(MP:0002962)

  • podocyte foot process effacement(MP:0008140)

  • premature death(MP:0002083)

  • renal cast(MP:0011402)

  • renal fibrosis(MP:0003985)

  • renal glomerular protein deposits(MP:0020518)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. Depending on the content of the research, the DEPOSITOR may request collaboration.
    DepositorNobuya Sasaki (Kitasato University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data