Strain Data Sheet

RBRC10429

Strain Information

Image
BRC No.RBRC10429
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6N(D2)-Jak1<spade>/RgscHko
Former Common nameSpade-B6N(N7)
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Hisahiro Yoshida RIKEN, in 2003. This strain was backcrossed to C57BL/6N for 7 generations.
Strain descriptionENU mutant mice for the Jak1 gene. A point mutation in the Jak1 gene, which increase a kinase activity of Jak1. Mutants develop dermatitis around 8 to 10 weeks of their age.
Colony maintenance
References
Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin B H, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
J. Clin. Invest., 126(6):2064-2076 (2016). 27111231

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Jak1
MGI:96628		Janus kinase 14Jak1<spade>
  • autoinflammation, immune dysregulation, and eosinophilia(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal T-helper 1 physiology(MP:0005465)

  • abnormal enzyme/coenzyme activity(MP:0005584)

  • abnormal epidermis stratum corneum morphology(MP:0001240)

  • abnormal fibroblast physiology(MP:0020414)

  • abnormal keratinocyte differentiation(MP:0002656)
    • more 13 phenotypes
  • abnormal keratinocyte physiology(MP:0003453)

  • abnormal keratinocyte proliferation(MP:0009582)

  • dermatitis(MP:0001194)

  • epidermal desquamation(MP:0001230)

  • epidermal hyperplasia(MP:0001222)

  • excessive scratching(MP:0001412)

  • impaired skin barrier function(MP:0002796)

  • increased IgE level(MP:0002497)

  • increased IgG1 level(MP:0008499)

  • increased IgG2b level(MP:0008501)

  • increased IgG2c level(MP:0008896)

  • increased circulating histamine level(MP:0030758)

  • mixed cellular infiltration to dermis(MP:0001246)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    covid19_onset
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHaruhiko Koseki (RIKEN)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data