Strain Data Sheet

RBRC10430

Strain Information

Image
BRC No.RBRC10430
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6J(D2)-Jak1<spade>/RgscHko
Former Common nameSpade-B6J(N10)
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Hisahiro Yoshida RIKEN, in 2003. This strain was backcrossed to C57BL/6J for 10 generations.
Strain descriptionENU mutant mice for the Jak1 gene. A point mutation in the Jak1 gene, which increase a kinase activity of Jak1. Mutants develop dermatitis around 8 to 10 weeks of their age.
Colony maintenance
References
Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.
Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin B H, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
J. Clin. Invest., 126(6):2064-2076 (2016). 27111231

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Jak1
MGI:96628		Janus kinase 14Jak1<spade>
  • autoinflammation, immune dysregulation, and eosinophilia(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDermatology Research
    covid19_onset
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorHaruhiko Koseki (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data