Strain Data Sheet

RBRC10433

Strain Information

Image
BRC No.RBRC10433
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameRunx2 (loxP) (Acc. No. CDB0832K)
Former Common nameRunx2 (loxP) (Acc. No. CDB0832K)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice.
Takarada T, Hinoi E, Nakazato R, Ochi H, Xu C, Tsuchikane A, Takeda S, Karsenty G, Abe T, Kiyonari H, Yoneda Y
J. Bone Miner. Res., 28(10):2064-9 (2013). 23553905

Health Report

Examination Date / Room / Rack2025/01/07Room:3-ARack:CSentinel mouse program
2024/10/07Room:3-ARack:CSentinel mouse program
2024/04/08Room:3-ARack:CSentinel mouse program
2024/01/09Room:3-ARack:CSentinel mouse program
2023/12/21Room:3-ARack:CAdditional tests
2023/10/10Room:3-ARack:CSentinel mouse program
2023/07/10Room:3-ARack:CSentinel mouse program
2023/04/10Room:3-ARack:CSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site17Frt
Runx2
MGI:99829		runt related transcription factor 217Runx2<tm1.1Yyon>
MGI:5570536		targeted mutation 1.1, Yukio Yoneda
  • cleidocranial dysplasia 1(DisGeNET, MedGEN)

  • metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome(MedGEN)
    • loxP phage P1 loxP17loxP
    loxP phage P1 loxP17loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • delayed bone ossification(MP:0000060)

  • delayed endochondral bone ossification(MP:0003419)

  • mortality/aging(MP:0010768)

  • neonatal lethality, complete penetrance(MP:0011087)

  • respiratory distress(MP:0001954)
    • more 1 phenotypes
  • skeleton phenotype(MP:0005390)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast Frt (flippase recombination target) site, mouse Runx2 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsThe RECIPIENT should prior contact Dr. Takeshi Takarada (takarada@okayama-u.ac.jp), the DEVELOPER scientist to obtain a permission and confirm the terms and conditions of use of the strain. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0832K and Web Site (https://large.riken.jp/distribution/mutant-list.html) is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (J. Bone Miner. Res. 2013 28(10):2064-2069.) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN BDR (RIKEN BDR)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data