Strain Data Sheet

RBRC10600

Strain Information

Image
BRC No.RBRC10600
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Adcy1<tm1Ito>
Former Common nameAC1-flox, Adcy1-flox
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Center for Brain Science. E14 ES cells derived from 129P2 was used. Mice were maintained by crossing to C57BL/6J for more than 10 generations. C57BL/6 congenic strain.
Strain descriptionFloxed mice for Adcy1 (adenylate cyclase 1). Exon 1 was flanked by a pair of loxP.
Colony maintenance
References
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
Iwasato T, Inan M, Kanki H, Erzurumlu R S, Itohara S, Crair M C
J. Neurosci., 28(23): 5931-5943 (2008). 18524897

Health Report

Examination Date / Room / Rack2024/10/07Room:3-BRack:BSentinel mouse program
2024/04/08Room:3-BRack:BSentinel mouse program
2024/01/09Room:3-BRack:BSentinel mouse program
2023/10/10Room:3-BRack:BSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Adcy1
MGI:99677		adenylate cyclase 111Adcy1<tm1Ito>
MGI:3798841		targeted mutation 1, Shigeyoshi Itohara
  • autosomal recessive nonsyndromic hearing loss 44(MedGEN)
    • Frt yeast FRT (flippase recombination target) site11Frt
    loxP phage P1 loxP11loxP
    loxP phage P1 loxP11loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAyeast FRT (flippase recombination target) site, phage P1 loxP sites, mouse Adcy1 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28(23): 5931-5943 (2008).
    DepositorShigeyoshi Itohara (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data