Strain Data Sheet

RBRC10601

Strain Information

Image
BRC No.RBRC10601
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Adcy1<tm1.1Ito>
Former Common nameAC1-null, Adcy1-knockout
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Center for Brain Science. E14 ES cells derived from 129P2 was used. Mice were maintained by crossing to C57BL/6J for more than 20 generations. C57BL/6 congenic strain.
Strain descriptionAdcy1 (adenylate cyclase 1) knockout mice. Exon 1 was deleted.
Colony maintenance
References
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
Iwasato T, Inan M, Kanki H, Erzurumlu R S, Itohara S, Crair M C
J. Neurosci., 28(23): 5931-5943 (2008). 18524897

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Adcy1
MGI:99677		adenylate cyclase 111Adcy1<tm1.1Ito>
MGI:3798842		targeted mutation 1.1, Shigeyoshi Itohara
  • autosomal recessive nonsyndromic hearing loss 44(MedGEN)
    • Frt yeast FRT (flippase recombination target) site11Frt
    loxP phage P1 loxP11loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal thalamus morphology(MP:0000832)

  • absent barrels in primary somatosensory cortex(MP:0000862)
    • Detailed phenotype data

    Ordering Information

    Donor DNA出芽酵母　FRT配列, P1ファージ　LoxP配列, マウス　AC1
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Neurosci. 2008 June 4; 28(23): 5931-5943. doi:10.1523/JNEUROSCI.0815-08.2008
    DepositorShigeyoshi Itohara (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data