Strain Data Sheet

RBRC10605

Strain Information

Image
BRC No.RBRC10605
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC57BL/6-Chn1<mfy>/Ito
Former Common namemiffy
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Center for Brain Science. Ryosuke Takahashi and Haruhisa Inoue found miffy mutants. Takuji Iwasato and Shigeyoshi Itohara identified causal gene.
Strain descriptionmiffy spontaneous mutant. A retroposon insertion at exon 9 of the Chn1 (chimerin 1), which resulted in loss of Rac-GAP activity and caused locomotor activity deficit.
Colony maintenance
References
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.
Iwasato T, Katoh H, Nishimaru H, Ishikawa Y, Inoue H, Saito Y M, Ando R, Iwama M, Takahashi R, Negishi M, Itohara S
Cell, 130 (4), 742-753 (2007). 17719550

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Chn1
MGI:1915674		chimerin 12Chn1<mfy>
MGI:3760001		miffy
  • Duane retraction syndrome 2(MedGEN)

    • Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cerebral cortex morphology (MP:0000788)

  • abnormal contextual conditioning behavior (MP:0001469)

  • abnormal corticospinal tract morphology (MP:0002878)

  • abnormal fear/anxiety-related behavior (MP:0002065)

  • abnormal gait (MP:0001406)
    • more 4 phenotypes
  • abnormal locomotor behavior (MP:0001392)

  • abnormal nervous system electrophysiology (MP:0002272)

  • abnormal spinal cord dorsal column morphology (MP:0009677)

  • decreased body weight (MP:0001262)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 130 (4), 742-753 (2007).
    DepositorShigeyoshi Itohara (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data