Strain Data Sheet

RBRC10608

Strain Information

Image
BRC No.RBRC10608
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Chn1<tm3.2Ito>
Former Common nameChn1 (alpha1 isoform) knockout
H-2 Haplotype
ES Cell lineMS12 [C57BL/6]
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Center for Brain Science. MS12 ES cells derived from C57BL6, and then mice were crossed to C57BL/6J.
Strain descriptionα1 chimaerin (chimerin) knockout mice. Exon 7 of the Chn1 gene containing transcription initiation site for α1 chimaerin (chimerin) was deleted.
Colony maintenance
References
RacGAP alpha2-chimaerin function in development adjusts cognitive ability in adulthood.
Iwata R, Ohi K, Kobayashi Y, Masuda A, Iwama M, Yasuda Y, Yamamori H, Tanaka M, Hashimoto R, Itohara S, Iwasato T
Cell Rep., 8(5) 1257-1264 (2014). 25159148

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Chn1
MGI:1915674		chimerin 12Chn1<tm3.2Ito>
MGI:5754367		targeted mutation 3.2, Shigeyoshi Itohara
  • Duane retraction syndrome 2(MedGEN)
    • Frt yeast FRT (flippase recombination target) site2Frt
    loxP phage P1 loxP2loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal fear/anxiety-related behavior(MP:0002065)

  • increased anxiety-related response(MP:0001363)
    • Detailed phenotype data

    Ordering Information

    Donor DNAP1ファージ LoxP配列, マウス Chn1
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Rep. 2014 Sep 11;8(5):1257- 64. doi: 10.1016/ j.celrep.2014.07.047. Epub 2014 Aug 21
    DepositorShigeyoshi Itohara (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data