Strain Data Sheet

RBRC10610

Strain Information

Image
BRC No.RBRC10610
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Chn1<tm2.2Ito>
Former Common nameChn1 (alpha2 isoform) knockout
H-2 Haplotype
ES Cell lineMS12 [C57BL/6]
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Center for Brain Science. MS12 ES cells derived from C57BL6, and then mice were crossed to C57BL/6J.
Strain descriptionα2 chimaerin (chimerin) knockout mice. Exon 6 of the Chn1 gene was deleted.
Colony maintenance
References
RacGAP alpha2-chimaerin function in development adjusts cognitive ability in adulthood.
Iwata R, Ohi K, Kobayashi Y, Masuda A, Iwama M, Yasuda Y, Yamamori H, Tanaka M, Hashimoto R, Itohara S, Iwasato T
Cell Rep., 8(5) 1257-1264 (2014). 25159148

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Chn1
MGI:1915674		chimerin 12Chn1<tm2.2Ito>
MGI:5754363		targeted mutation 2.2, Shigeyoshi Itohara
  • Duane retraction syndrome 2(MedGEN)
    • loxP phage P1 loxP2loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal contextual conditioning behavior(MP:0001469)

  • enhanced conditioned place preference behavior(MP:0009713)

  • enhanced contextual conditioning behavior(MP:0009453)

  • impaired avoidance learning behavior(MP:0012312)
    • Detailed phenotype data

    Ordering Information

    Donor DNAマウス Chn1, P1ファージ LoxP配列
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Rep. 2014 Sep 11;8(5):1257- 64. doi: 10.1016/ j.celrep.2014.07.047. Epub 2014 Aug 21
    DepositorShigeyoshi Itohara (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data