Strain Data Sheet

RBRC10782

Strain Information

Image
BRC No.RBRC10782
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameB6-Rr(PCS1-MRCS1)<em1Tshir>/Ms
Former Common namedeltaPCS1-MRCS1
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Toshihiko Shiroishi and Takanori Amano, National Institute of Genetics in 2015 with the CRISPR/Cas9 technique. C57BL/6 genetic background.
Strain descriptionDeletion mutant of PCS1 and MRCS1 enhancer of Shh gene.
Colony maintenance
References
Upstream Enhancer Elements of Shh Regulate Oral and Dental Patterning.
Seo H, Amano T, Seki R, Sagai T, Kim J, Cho S W, Shiroishi T
J. Dent. Res., 97: 1055-1063 (2018). 29481312

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Shh
MGI:98297		sonic hedgehog5Shh<em1Tshir> endonuclease-mediated mutation 1, Toshihiko Shiroishi
  • holoprosencephaly 3(DisGeNET, MedGEN)

  • microphthalmia, isolated, with coloboma 5(MedGEN)

  • schizencephaly(MedGEN)
    • more 1 Diseases
  • solitary median maxillary central incisor syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Dent. Res., 97: 1055-1063 (2018).
    DepositorToshihiko Shiroishi (National Institute of Genetics)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data