Strain Data Sheet

RBRC10789

Strain Information

Image
BRC No.RBRC10789
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6N-Ttr<tm1.1(NLS/cre)Card>
Former Common nameTtr-Cre
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Michihiko Sugimoto and Kimi Araki at Card, Kumamoto University in 2017. 6NK-7 ES cells derived from C57BL/6N were used to generate this strain. C57BL/6N genetic background.
Strain descriptionKnockin mice in which NLS-Cre replaced the coding sequence for the Ttr gene.
Colony maintenance
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
En2 En2 SA (mouse En2 intron 2/exon 3 splice acceptor sequence)18En2
HBB2 rabbit beta-globin intron18HBB2
Ttr
MGI:98865
transthyretin18Ttr<tm1.1(NLS/cre)Card> targeted mutation 1.1, Center for Animal Resources & Development
  • carpal tunnel syndrome(DisGeNET)

  • familial amyloid neuropathy(DisGeNET, MedGEN)

  • hyperthyroxinemia, dystransthyretinemic(MedGEN)
  • cre Phage P1 Cre recombinase18cre
    loxP phage P1 loxP18loxP
    nls SV40 large T antigen nuclear localization signal (NLS)18nls

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNASV40 large T antigen nuclear localization signal (NLS), Rabbit beta-globin intron, mouse En-2 intron/exron splicing acceptor, Phage P1 Cre, mouse Pgk polyA signal, Phage P1 loxP site, mouse Ttr genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 本系統を用いて公表された第一報の論文In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent form the DEPOSITOR.
    DepositorKimi Araki (Kumamoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data