Strain Data Sheet

RBRC10896

Strain Information

Image
BRC No.RBRC10896
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Mapk1<tm2.1Moga>
Former Common nameERK2 flox
H-2 Haplotype
ES Cell lineEB3 [129/Ola]
Background strain
Appearance
Strain developmentA floxed mutant mice possess loxP sites flanking the ERK2 gene established by M. Ogata, et al., in 2003. This strain may be useful for generating conditional mutations of ERK2. C57BL/6 congenic strain by backcrossing over 8 generations.
Strain descriptionERK2 flox strain. A pair of loxP flanks exon 3 of the Mapk1 gene.
Colony maintenance
References
Essential role for ERK2 mitogen-activated protein kinase in placental development.
Hatano N, Mori Y, Oh-hora M, Kosugi A, Fujikawa T, Nakai N, Niwa H, Miyazaki J, Hamaoka T, Ogata M
Genes Cells, 8(11):847-56 (2003). 14622137

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.
Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T
Immunity, 28(4):499-508 (2008). 18356083

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mapk1
MGI:1346858		mitogen-activated protein kinase 116Mapk1<tm2.1Moga> targeted mutation 2.1, Masato Ogata
  • Noonan syndrome 13(MedGEN)
    • loxP phage P1 loxP16loxP
    loxP phage P1 loxP16loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage Pl loxP sites, Mouse Mapk1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes to Cells. 8, 847-856 (2003). Immunity, 28(4):499-508 (2008). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorMasato Ogata (Mie University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data