Strain Data Sheet

RBRC10944

Strain Information

Image
BRC No.RBRC10944
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Aicda<tm1.2Evo>
Former Common nameAicda-FL
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Kazuo Kinoshita, Shiga Medical Center Research Institute in 2019. Bruce 4 ES cells were used. C57BL/6 congenic line.
Strain descriptionAicda floxed mice. A pair of lox P flanks Exon2 and 3 of the Aicda.
Colony maintenance
References
Stepwise generation of AID knock-in and conditional knockout mice from a single gene-targeting event.
Kinoshita K, Uemura M, Shimizu T, Kinoshita S, Marusawa H
Int. Immunol., 33(7):387-398 (2021). 33903914

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Aicda
MGI:1342279		activation-induced cytidine deaminase6Aicda<tm1.2Evo> targeted mutation 1.2, Kazuo Kinoshita
  • hyper-IgM syndrome type 2(MedGEN)
    • loxP phage P1 loxP6loxP
    loxP phage P1 loxP6loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage P1 loxP sites, mouse Aicda genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. Immunol., 33(7):387-398 (2021). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorKazuo Kinoshita (Shiga Medical Center Research Institute)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data